UNC-Chapel Hill reaches milestone in development of Kinase Chemogenomic Set

(University of North Carolina at Chapel Hill) The Structural Genomics Consortium at the University of North Carolina at Chapel Hill (SGC-UNC), in partnership with the DiscoverX Corporation, has reached the milestone halfway point in its development of the Kinase Chemogenomic Set, a potent group of inhibitors which allow deeper exploration of the human kinome, a family of enzymes critical to understanding human disease and developing new therapies.

Advertisements

Stressed-out rats consume more alcohol, revealing related brain chemistry

(University of Pennsylvania School of Medicine) Researchers found that rodents that had been exposed to stress had a weakened alcohol-induced dopamine response and voluntarily drank more alcohol compared to controls. The blunted dopamine signaling to ethanol arose due to changes in the circuitry in the ventral tegmental area, the heart of the brain’s reward system.